FOXP3: not just for regulatory T cells anymore

Eur J Immunol. 2007 Jan;37(1):21-3. doi: 10.1002/eji.200636929.


The forkhead family transcription factor FOXP3 has been shown to be critical for the development and function of CD4+ CD25+ regulatory T cells. Recently, FOXP3 expression has been shown to be induced upon activation of human CD4+ T cells. A new report in this issue of the European Journal of Immunology shows that expression of FOXP3 in activated T cell leads to hyporesponsiveness, but not necessarily to acquisition of suppressor function. This finding suggests a new role for FOXP3 in human CD4+ T cells: down-modulating responses to TCR-mediated stimulation.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Down-Regulation / immunology
  • Forkhead Transcription Factors / physiology*
  • Humans
  • Lymphocyte Activation / immunology
  • Receptors, Antigen, T-Cell / antagonists & inhibitors
  • Receptors, Antigen, T-Cell / physiology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism*


  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Receptors, Antigen, T-Cell