[Active constituents from Aloe arborescens as BACE inhibitors]

Yao Xue Xue Bao. 2006 Oct;41(10):1000-3.
[Article in Chinese]

Abstract

Aim: To seek for new components as BACE inhibitors from Aloe arborescens.

Methods: The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.

Results: Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.

Conclusion: Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors*
  • Amyloid Precursor Protein Secretases / metabolism
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification
  • Anthraquinones / pharmacology
  • Aspartic Acid Endopeptidases / antagonists & inhibitors*
  • Aspartic Acid Endopeptidases / metabolism
  • Chromones / chemistry
  • Chromones / isolation & purification
  • Chromones / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Humans
  • Molecular Conformation
  • Molecular Structure
  • Plant Components, Aerial / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry
  • Pyrones / chemistry
  • Pyrones / isolation & purification
  • Pyrones / pharmacology

Substances

  • 2-acetonyl-8-(2'-O-feruloxyl)glucopyranosyl-7-methoxy-5-methylchromone
  • 6'-O-isobutyryl aloenin A
  • Anthraquinones
  • Chromones
  • Enzyme Inhibitors
  • Glucosides
  • Plant Extracts
  • Pyrones
  • elgonica dimer A
  • Amyloid Precursor Protein Secretases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human