Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS

Endocrine. 2006 Aug;30(1):45-53. doi: 10.1385/ENDO:30:1:45.


Polycystic ovary syndrome is the most common endocrinopathy of reproductive aged women affecting 6-10% of the population. Traditionally considered a reproductive disorder manifesting as chronic anovulation, infertility, and hyperandrogenism, management has primarily focused on short-term reproductive outcomes. Recently, however, significant metabolic aspects in conjunction with longer-term health sequealae of PCOS have been recognized. The metabolic features are primarily related to underlying insulin resistance (IR), which is now understood to play an important role in both the pathogenesis and long-term sequelae of PCOS.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / metabolism
  • Diabetes Mellitus / metabolism
  • Female
  • Humans
  • Insulin Resistance / physiology*
  • Metabolic Syndrome / complications*
  • Metabolic Syndrome / metabolism
  • Polycystic Ovary Syndrome / complications*
  • Polycystic Ovary Syndrome / metabolism
  • Risk Factors