Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes

J Musculoskelet Neuronal Interact. 2006 Oct-Dec;6(4):358-9.

Author

T Bellido¹

Affiliation

¹ Division of Endocrinology, Department of Internal Medicine and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. tmbellido@uams.edu

PMID: 17185824

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing
Animals
Apoptosis / physiology
Bone Density / physiology
Bone Morphogenetic Proteins / genetics
Bone Morphogenetic Proteins / metabolism*
Cell Count
Core Binding Factor Alpha 1 Subunit / physiology
Down-Regulation / physiology*
Genetic Markers / genetics
Glycoproteins
Intercellular Signaling Peptides and Proteins
Mice
Mice, Transgenic
Osteoblasts / cytology
Osteoblasts / physiology
Osteocytes / cytology
Osteocytes / physiology*
Osteogenesis / physiology*
Parathyroid Hormone / physiology*
Receptor, Parathyroid Hormone, Type 1 / physiology

Substances

Adaptor Proteins, Signal Transducing
Bone Morphogenetic Proteins
Core Binding Factor Alpha 1 Subunit
Genetic Markers
Glycoproteins
Intercellular Signaling Peptides and Proteins
Parathyroid Hormone
Receptor, Parathyroid Hormone, Type 1
Runx2 protein, mouse
Sost protein, mouse