[Trial of isolation of sick house syndrome and unclassified multiple chemical sensitivities--Definition of sick house syndrome, and symptoms]

Arerugi. 2006 Dec;55(12):1515-30.
[Article in Japanese]


Purpose: This study was designed to clarify the definition of sick house syndrome (SHS).

Methods: SHS was defined based on the disease related to habitation as follows. 1. The cause of the onset of a disease relates to house. 2. Symptoms appear within house. 3. Symptoms will be less serious or disappear if patient away from house. 4. If patient goes into house, symptoms will appear repeatedly. When it corresponded to all above, it was defined to SHS, and it classified as MCS (multiple chemical sensitivities) without above conditions. Even if SHS is isolated from similar disease completely, characteristic symptoms of MCS are hard to be detected because MCS are combination of two or more diseases. Based on this working hypothesis, the logistic regression by setting MCS as reference was performed so that characteristic symptoms of SHS show odds ratios with exceeding one.

Results: The odds ratios with more than two of characteristic symptoms in SHS were "nausea or vomiting" "Troublesome in everything" and the causative substances to which symptoms get worse was "The smell of a perfume and cosmetics". Characteristic symptoms of an allergy disease were detected by comparison with the allergic conjunctivitis, allergic rhinitis, and bronchial asthma, respectively.

Conclusion: These results showed that the classification method was appropriate. This definition is not fundamentally differed from the definition of the sick-building syndrome of WHO.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air Pollution, Indoor / analysis*
  • Environmental Illness / diagnosis
  • Environmental Illness / etiology
  • Female
  • Humans
  • Male
  • Multiple Chemical Sensitivity / classification
  • Multiple Chemical Sensitivity / etiology
  • Regression Analysis
  • Sick Building Syndrome* / classification
  • Sick Building Syndrome* / diagnosis
  • Sick Building Syndrome* / etiology