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Comparative Study
. 2007 Apr;116(2):185-95.
doi: 10.1007/s00412-006-0090-4. Epub 2006 Dec 21.

The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster

Tibor Török  1 , Cecil Benitez, Sándor Takács, Harald Biessmann
Affiliations
Comparative Study

The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster

Tibor Török et al. Chromosoma. 2007 Apr.

Abstract

We report in this paper that the PROD protein, encoded by the gene proliferation disrupter (prod), is associated with the telomeric chromatin in Drosophila melanogaster. It binds to a region just upstream of the promoter of the telomere-specific retrotransposon HeT-A, which is located in the long 3'untranslated region of the element near its oligo(A) tail. Reduction of PROD in prod heterozygote flies results in elevated levels of HeT-A RNA in the ovaries, suggesting that PROD functions as a repressor of HeT-A transcriptional activity at the telomeres.

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