Transient severe metastatic calcification in acute renal failure

Pediatr Nephrol. 2007 Apr;22(4):607-11. doi: 10.1007/s00467-006-0387-9. Epub 2006 Dec 21.


Metastatic calcification, a known complication of prolonged end-stage renal disease, is herein described for the first time in a 10-month-old boy with acute renal failure, manifesting as a painful and swollen arm. Imaging revealed diffuse calcification and technetium-99 methylene diphosphonate (99Tc-MDP) uptake around the humerus and axilla. Calcium and vitamin D restriction, followed by intravenous administration of sodium thiosulfate caused a full symptomatic, radio- and scintigraphic improvement.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / complications*
  • Acute Kidney Injury / therapy
  • Calcinosis / diagnosis
  • Calcinosis / etiology*
  • Calcinosis / therapy
  • Humans
  • Infant
  • Male
  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate


  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate