Role of bone morphogenetic proteins in cardiac differentiation

Cardiovasc Res. 2007 May 1;74(2):244-55. doi: 10.1016/j.cardiores.2006.11.022. Epub 2006 Nov 21.


Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs in the formation of the ventricular chambers and septovalvulogenesis in the atrioventricular canal and outflow tract is described. Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / physiology*
  • Cell Differentiation / physiology
  • Heart / embryology*
  • Heart Ventricles
  • Humans
  • Morphogenesis / physiology
  • Myocytes, Cardiac / cytology
  • Signal Transduction / physiology


  • Bone Morphogenetic Proteins