New functions for Y family polymerases

Mol Cell. 2006 Nov 17;24(4):493-5. doi: 10.1016/j.molcel.2006.10.021.

Abstract

The Y family of DNA polymerases plays crucial roles in carrying out translesion synthesis past damaged bases in DNA. Several recent papers suggest that they might have other roles as well in gene conversion, in nucleotide excision repair (NER), and in DNA replication under stressed conditions.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • DNA Repair*
  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / physiology*
  • Humans
  • Nuclear Proteins
  • Nucleotidyltransferases / physiology
  • Recombination, Genetic

Substances

  • Nuclear Proteins
  • Nucleotidyltransferases
  • REV1 protein, human
  • DNA-Directed DNA Polymerase