Photoreceptor status after resolved macular edema in branch retinal vein occlusion treated with tissue plasminogen activator

Am J Ophthalmol. 2007 Jan;143(1):171-3. doi: 10.1016/j.ajo.2006.08.030. Epub 2006 Sep 28.


Purpose: To evaluate the integrity of photoreceptors in macular edema (ME) associated with branch retinal vein occlusion after intravitreal tissue plasminogen activator.

Design: Retrospective, interventional case series.

Methods: Nineteen eyes with ME by branch retinal vein occlusion were treated with intravitreal tissue plasminogen activator injection. We assessed visual acuity (VA) and the presence or absence in the fovea of a third high reflectance band (HRB) by optical coherence tomography at the final visit.

Results: No differences were found in age, preoperative VA, and foveal thickness between the groups with or without the third HRB. After treatment, the mean VA improved significantly (P < .05) in both groups. At the final visit, the mean VA in the group without HRB was significantly poorer than the group with HRB (P = .0042); foveal thickness did not differ between the groups.

Conclusions: The integrity of the third HRB in the fovea is associated with VA after the resolution of ME.

MeSH terms

  • Female
  • Fibrinolytic Agents / therapeutic use*
  • Fovea Centralis
  • Humans
  • Injections
  • Macular Edema / drug therapy*
  • Macular Edema / etiology
  • Male
  • Middle Aged
  • Photoreceptor Cells, Vertebrate / pathology*
  • Retinal Vein Occlusion / complications*
  • Retrospective Studies
  • Tissue Plasminogen Activator / therapeutic use*
  • Tomography, Optical Coherence
  • Venous Pressure
  • Visual Acuity / physiology
  • Vitreous Body


  • Fibrinolytic Agents
  • Tissue Plasminogen Activator