Sequestosome 1/p62--more than just a scaffold

FEBS Lett. 2007 Jan 23;581(2):175-9. doi: 10.1016/j.febslet.2006.12.027. Epub 2006 Dec 19.


The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Humans
  • Protein Structure, Tertiary
  • Proteins / chemistry*
  • Proteins / genetics
  • Proteins / metabolism*
  • Sequestosome-1 Protein
  • Ubiquitin / metabolism


  • Adaptor Proteins, Signal Transducing
  • Proteins
  • SQSTM1 protein, human
  • Sequestosome-1 Protein
  • Ubiquitin