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Case Reports
. 2007 May;56(5):877-80.
doi: 10.1016/j.jaad.2006.11.005. Epub 2006 Dec 22.

Rapidly Growing Collagenomas in Multiple Endocrine Neoplasia Type I

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Case Reports

Rapidly Growing Collagenomas in Multiple Endocrine Neoplasia Type I

Yang Xia et al. J Am Acad Dermatol. .

Abstract

Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas. We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses. Five of the collagenomas were protuberant, with the bulk of the lesion protruding above the skin. Histologic analysis of the collagenomas revealed broad collagen bundles in a haphazard arrangement and decreased elastic fibers. Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma.

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