The purpose of this article is to offer rationale to support the argument for research testing of tailored interventions. The individualization of nursing interventions is used as a basis for discussion of the emergent need to test tailored interventions at the research rather than practice level. Both justification of efficacy and feasibility support the research testing of tailored interventions, in support of an evolving nursing process. In order to retain its patient-centered focus and yet meet scientific standards for practice, nursing must evaluate the individualization of care through more theory-based and systematic research processes. The testing of tailored interventions at the research level would provide a means to achieve these ends.