In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum

Biomed Environ Sci. 2006 Oct;19(5):367-70.


Objective: To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.

Method: Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.

Results: DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.

Conclusion: Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / pharmacokinetics*
  • Antimalarials / pharmacology
  • Plasmodium falciparum / drug effects*
  • Umbelliferones / chemistry
  • Umbelliferones / pharmacokinetics*
  • Umbelliferones / pharmacology


  • Antimalarials
  • Umbelliferones
  • daphnetin