Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test

Diabetes Care. 2007 Jan;30(1):89-94. doi: 10.2337/dc06-1519.

Abstract

Objective: To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT).

Research design and methods: A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m(2)) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis.

Results: The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose(0-30)[AUC] x insulin(0-30)[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001).

Conclusions: Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Glucose Intolerance / physiopathology
  • Glucose Tolerance Test*
  • Hispanic Americans
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Liver / physiology*
  • Liver / physiopathology
  • Middle Aged
  • Muscle, Skeletal / physiology*
  • Muscle, Skeletal / physiopathology
  • Reference Values

Substances

  • Insulin