A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Chem Biodivers. 2006 Jan;3(1):101-5. doi: 10.1002/cbdv.200690000.

Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification*
  • Drugs, Chinese Herbal*
  • Garcinia*
  • Humans
  • K562 Cells
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Xanthones / chemistry
  • Xanthones / isolation & purification*

Substances

  • Cytotoxins
  • Drugs, Chinese Herbal
  • Plant Extracts
  • Xanthones