Abstract
Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cytotoxins / chemistry
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Cytotoxins / isolation & purification*
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Drugs, Chinese Herbal*
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Garcinia*
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Humans
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K562 Cells
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Xanthones / chemistry
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Xanthones / isolation & purification*
Substances
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Cytotoxins
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Drugs, Chinese Herbal
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Plant Extracts
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Xanthones