Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities

Chem Biodivers. 2006 Sep;3(9):990-5. doi: 10.1002/cbdv.200690108.

Abstract

Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)-8-[(R)-1-hydroxyethyl]dihydrochelerythrine (1) and 8-methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8-methoxychelerythrine (6), and 8-hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti-inflammatory effects as hydrocortisone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal* / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal* / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal* / therapeutic use
  • Benzophenanthridines* / chemistry
  • Benzophenanthridines* / isolation & purification
  • Benzophenanthridines* / therapeutic use
  • Edema / drug therapy
  • Male
  • Mice
  • Molecular Structure
  • Pain / drug therapy
  • Plant Roots / chemistry
  • Structure-Activity Relationship
  • Zanthoxylum / chemistry*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzophenanthridines