Shaping the actin cytoskeleton using microtubule tips

Curr Opin Cell Biol. 2007 Feb;19(1):88-94. doi: 10.1016/ Epub 2006 Dec 27.


The microtubule cytoskeleton serves as a primary spatial regulator of cell shape. As part of their function, microtubules appear to activate or inhibit the actin cytoskeleton at specific locations at the cell cortex for cell polarization, cell migration and cytokinesis. Recent studies reveal molecular insights into these processes. Regulators of the actin cytoskeleton, such as activators of formin and Rho GTPases, are transported to specific sites on the cortex by riding on the plus ends of microtubules.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actins / physiology*
  • Animals
  • Cell Movement / physiology
  • Cell Polarity / physiology
  • Cell Shape / physiology*
  • Cytokinesis / physiology
  • Cytoskeleton / physiology*
  • Microtubules / physiology*
  • Protein Transport


  • Actins