High affinity not in the vicinity?

Neuron. 2007 Jan 4;53(1):1-4. doi: 10.1016/j.neuron.2006.12.018.

Abstract

Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure of the full TrkA ectodomain complexed to NGF and examine the possibility of a ternary p75NTR-NGF-TrkA complex.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Binding Sites / physiology
  • Humans
  • Ligands
  • Macromolecular Substances / chemistry
  • Macromolecular Substances / metabolism
  • Nerve Growth Factor / chemistry*
  • Nerve Growth Factor / metabolism
  • Neurons / metabolism*
  • Protein Structure, Tertiary / physiology
  • Receptor, Nerve Growth Factor / chemistry*
  • Receptor, Nerve Growth Factor / metabolism
  • Receptor, trkA / chemistry*
  • Receptor, trkA / metabolism
  • Signal Transduction / physiology

Substances

  • Ligands
  • Macromolecular Substances
  • Receptor, Nerve Growth Factor
  • Nerve Growth Factor
  • Receptor, trkA