Mechanisms of vascular calcification

Adv Chronic Kidney Dis. 2007 Jan;14(1):54-66. doi: 10.1053/j.ackd.2006.10.007.

Abstract

Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important contributory factors for vascular calcification in these patients. This article reviews current mechanisms proposed for the regulation of vascular calcification and data supporting their potential contribution to this process in chronic kidney disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antifibrinolytic Agents / pharmacology
  • Blood Proteins / metabolism
  • Bone Density Conservation Agents / therapeutic use
  • Bone Morphogenetic Proteins / metabolism
  • Calcinosis / etiology
  • Calcinosis / metabolism*
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Chronic Disease
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / metabolism
  • Humans
  • Kidney Diseases / metabolism*
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / metabolism
  • Mice
  • Parathyroid Hormone / metabolism
  • Phosphates / metabolism
  • Rats
  • Vascular Diseases / etiology
  • Vascular Diseases / metabolism*
  • Vitamin D / therapeutic use
  • Vitamin K / pharmacology
  • alpha-2-HS-Glycoprotein

Substances

  • AHSG protein, human
  • Ahsg protein, mouse
  • Antifibrinolytic Agents
  • Blood Proteins
  • Bone Density Conservation Agents
  • Bone Morphogenetic Proteins
  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • Parathyroid Hormone
  • Phosphates
  • alpha-2-HS-Glycoprotein
  • matrix Gla protein
  • Vitamin K
  • Vitamin D