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Review
. Winter 2006;9(4):451-8.
doi: 10.1089/jmf.2006.9.451.

Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of catechol-O-methyltransferase

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Review

Green Tea Extract Thermogenesis-Induced Weight Loss by Epigallocatechin Gallate Inhibition of catechol-O-methyltransferase

Q Shixian et al. J Med Food. .

Abstract

Epidemiological studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin epigallocatechin gallate. That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis. Knowledge about thermogenesis-induced weight loss produced by green tea's epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft.

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