Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats

J Med Food. 2006 Winter;9(4):531-6. doi: 10.1089/jmf.2006.9.531.


We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an antilipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic properties and/or its antioxidant properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Fatty Acids, Nonesterified / blood
  • Isoproterenol*
  • Lipid Peroxidation / drug effects
  • Male
  • Myocardial Infarction / blood
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / prevention & control*
  • Myocardium / chemistry
  • Phospholipids / analysis
  • Phospholipids / blood
  • Rats
  • Rats, Wistar
  • Squalene / therapeutic use*
  • Triglycerides / blood


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Fatty Acids, Nonesterified
  • Phospholipids
  • Triglycerides
  • Squalene
  • Cholesterol
  • Isoproterenol