Fc receptor-like molecules

Annu Rev Immunol. 2007;25:525-60. doi: 10.1146/annurev.immunol.25.022106.141541.

Abstract

Discovery of a large family of Fc receptor-like (FCRL) molecules, homologous to the well-known receptors for the Fc portion of immunoglobulin (FCR), has uncovered an impressive abundance of immunoglobulin superfamily (IgSF) genes in the human 1q21-23 chromosomal region and revealed significant diversity for these genes between humans and mice. The observation that FCRL representatives are members of an ancient multigene family that share a common ancestor with the classical FCR is underscored by their linked genomic locations, gene structure, shared extracellular domain composition, and utilization of common cytoplasmic tyrosine-based signaling elements. In contrast to the conventional FCR, however, FCRL molecules possess diverse extracellular frameworks, autonomous or dual signaling properties, and preferential B lineage expression. Most importantly, there is no strong evidence thus far to support a role for them as Ig-binding receptors. These characteristics, in addition to their identification in malignancies and autoimmune disorders, predict a fundamental role for these receptors as immunomodulatory agents in normal and subverted B lineage cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • B-Lymphocytes / immunology*
  • Chromosomes, Human, Pair 1 / genetics
  • Chromosomes, Human, Pair 1 / immunology*
  • Gene Expression Regulation / immunology
  • Humans
  • Multigene Family / genetics
  • Multigene Family / immunology*
  • Neoplasms / genetics
  • Neoplasms / immunology
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / immunology*
  • Signal Transduction / genetics
  • Signal Transduction / immunology*

Substances

  • Receptors, Immunologic