Interictal depression, anxiety, personality traits, and psychological dissociation in patients with temporal lobe epilepsy (TLE) and extra-TLE

Epilepsia. 2006 Dec;47(12):2092-103. doi: 10.1111/j.1528-1167.2006.00808.x.

Abstract

Purpose: This study was performed to investigate the relation between symptoms of interictal depression, anxiety, personality traits, and psychological dissociation with the localization and lateralization of the epileptogenic zone in patients with partial epilepsy.

Methods: All patients were diagnosed according to the localization-related concept of the 1989 International League Against Epilepsy (ILAE) Classification of Epilepsies and Epileptic Syndromes, and the localization and lateralization of the epileptogenic zone was established by using the clinical criteria for noninvasive presurgical evaluation. This resulted in 67 patients with temporal lobe epilepsy (TLE) and 64 patients with extra-TLE. All patients were assessed on the various aspects of psychopathology by using a comprehensive battery of standardized diagnostic instruments.

Results: We did not find the hypothesized excess of psychiatric symptoms in patients with (mesial) TLE in comparison with patients with extra-TLE. We also found no differences between patients with the lateralization of epilepsy in the left versus the right hemisphere.

Conclusions: TLE per se cannot be considered a risk factor in developing more or more severe symptoms of psychopathology in patients with partial epilepsy. Concomitant factors, such as the duration of epilepsy, seizure frequency, and frontal lobe dysfunction may play an additional role. Our findings support the hypothesis of a multifactorial explanation for the psychiatric symptoms in patients with epilepsy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / epidemiology
  • Brain Mapping
  • Comorbidity
  • Depressive Disorder / diagnosis
  • Depressive Disorder / epidemiology
  • Diagnostic and Statistical Manual of Mental Disorders
  • Dissociative Disorders / diagnosis
  • Dissociative Disorders / epidemiology
  • Electroencephalography / statistics & numerical data
  • Epilepsies, Partial / diagnosis*
  • Epilepsies, Partial / epidemiology*
  • Epilepsies, Partial / psychology
  • Epilepsy, Temporal Lobe / diagnosis*
  • Epilepsy, Temporal Lobe / epidemiology*
  • Epilepsy, Temporal Lobe / psychology
  • Female
  • Frontal Lobe / physiopathology
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mental Disorders / diagnosis*
  • Mental Disorders / epidemiology*
  • Mental Disorders / psychology
  • Middle Aged
  • Personality Disorders / diagnosis
  • Personality Disorders / epidemiology
  • Personality Inventory
  • Prevalence
  • Psychiatric Status Rating Scales
  • Videotape Recording