A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia

Int Urol Nephrol. 2007;39(3):879-86. doi: 10.1007/s11255-006-9106-5. Epub 2007 Jan 4.


Introduction: Increasing attention has been focused on the use of phytotherapeutic agents to alleviate the symptoms of benign prostatic hyperplasia (BPH) in recent times. The best described and studied phytotherapeutic agent is Serenoa repens (SR).

Materials and methods: This prospective study was designed to have 3 arms including SR 320 mg per day (N = 20), Tamsulosin (TAM) 0.4 mg per day (N = 20) and SR + TAM (N = 20) to reveal the superiority or equivalence between these treatment regimens in BPH.

Results: The groups were not statistically different with regard to increase in maximal urinary flow rate (Q (max)) and decrease in International Prostate Symptom Score (I-PSS) (P > 0.05). No adverse effect was detected in SR therapy group.

Conclusion: Treatment of BPH by both SR and TAM seems to be effective alone. None of them had superiority to another and additionally, combined therapy (SR + TAM) does not provide extra benefits. Furthermore SR is a well-tolerated agent that can be used alternatively in the treatment of LUTS due to BPH.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adrenergic alpha-1 Receptor Antagonists*
  • Adult
  • Aged
  • Drug Therapy, Combination
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Prospective Studies
  • Prostatic Hyperplasia / drug therapy*
  • Serenoa
  • Sulfonamides / therapeutic use*
  • Tamsulosin
  • Treatment Outcome


  • Adrenergic alpha-1 Receptor Antagonists
  • Plant Extracts
  • Sulfonamides
  • Tamsulosin
  • saw palmetto extract