Leber hereditary optic neuropathy possibly triggered by exposure to tire fire

J Neuroophthalmol. 2006 Dec;26(4):268-72. doi: 10.1097/01.wno.0000249320.27110.ab.

Abstract

We report three members of one family, a mother and two daughters aged 4 and 7 years, who developed visual loss from Leber hereditary optic neuropathy within a 19-month period. All three had been exposed to smoke from two large rubber tire fires within the previous 24 months, suggesting the possibility of an epigenetic triggering factor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollutants / adverse effects*
  • Carbon / adverse effects
  • Child
  • Child, Preschool
  • DNA Mutational Analysis
  • DNA, Mitochondrial / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Mutation / genetics
  • Optic Atrophy, Hereditary, Leber / diagnosis
  • Optic Atrophy, Hereditary, Leber / etiology*
  • Optic Atrophy, Hereditary, Leber / physiopathology
  • Optic Nerve / pathology
  • Optic Nerve / physiopathology
  • Pedigree
  • Petroleum / adverse effects
  • Rubber / adverse effects

Substances

  • Air Pollutants
  • DNA, Mitochondrial
  • Petroleum
  • Carbon
  • Rubber