Chromatin modification and remodeling in heart development

ScientificWorldJournal. 2006 Apr 24;6:1851-61. doi: 10.1100/tsw.2006.315.

Abstract

In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have tissue-specific function. Here we review the potential roles for chromatin-remodeling and -modifying proteins in the development of the mammalian heart.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly / physiology*
  • Heart / embryology*
  • Heart / growth & development
  • Histones / metabolism
  • Histones / physiology
  • Humans
  • Models, Biological
  • Organogenesis / physiology

Substances

  • Chromatin
  • Histones