A retrospective cohort study compared the survival time of AIDS patients, or HIV infected patients who had a CD4 count less than 200 cell/mm3, who had Thailands local triple anti-retroviral drugs regimen (GPO-VIR) with original triple anti-retroviral therapy without protease inhibitor in Bamrasnaradura Institute. The result proved that survival time in patients who had local anti-retroviral drugs was the same as patients who had original triple anti-retroviral therapy without protease inhibitor (log rank p-value = 0.9617). In conclusion, local anti-retroviral drugs can be used to prolong patients' survival time as much as original triple anti-retroviral therapy without protease inhibitor