Apolipoprotein A-IV is an independent predictor of disease activity in patients with inflammatory bowel disease

Inflamm Bowel Dis. 2007 Apr;13(4):391-7. doi: 10.1002/ibd.20078.


Background: ApoA-IV, an apolipoprotein (apo) with antioxidant, antiatherogenic, and antiinflammatory properties, was recently demonstrated to inhibit dextran sulfate sodium (DSS)-induced experimental colitis in mice. We therefore hypothesized that apoA-IV may be associated with disease activity in patients with inflammatory bowel disease (IBD).

Methods: We addressed this question by testing for associations between apoA-IV genotypes, apoA-IV plasma levels, inflammatory parameters, and clinical disease activity in 206 patients with Crohn's disease (CD), 95 subjects with ulcerative colitis (UC), and 157 healthy controls.

Results: In CD patients, apoA-IV plasma levels were inversely associated with C-reactive protein (CRP) (P = 0.005) and disease activity (P = 0.01) in univariate analysis. In multiple logistic regression analysis, apoA-IV levels were identified as an independent predictor of elevated CRP (odds ratio [OR] 0.956, 95% confidence interval [CI]: 0.916-0.998, P = 0.04) and active disease (OR 0.957, 95% CI: 0.918-0.998, P = 0.04). In UC patients the apoA-IV gene variant 360 His (P = 0.03) but not apoA-IV levels (P = 0.15) were associated with increased disease activity in univariate analysis. This association, however, was lost in multiple logistic regression analysis (OR 3.435, 95% CI 0.995-11.853, P = 0.05).

Conclusions: To our knowledge, this is the first study to demonstrate an association of apoA-IV with disease activity in patients with CD. Further studies are needed to define the relationship of apoA-IV to IBD.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apolipoproteins A / blood*
  • Apolipoproteins A / genetics*
  • Biomarkers / blood
  • Case-Control Studies
  • Colitis, Ulcerative / diagnosis*
  • Colitis, Ulcerative / genetics
  • Crohn Disease / diagnosis*
  • Crohn Disease / genetics
  • Female
  • Genetic Markers
  • Humans
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Polymorphism, Genetic*
  • Recurrence


  • Apolipoproteins A
  • Biomarkers
  • Genetic Markers