Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations

J Pharm Pharm Sci. 2006;9(3):339-58.


It is, sometimes, desirable to maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an important area of pharmaceutical research and development. Of these systems, Pluronic F-127 (PF-127) provides the pharmacist with an excellent drug delivery system for a number of routes of administration and is compatible with many different substances. Gels containing penetration enhancers have proven to be especially popular for administering anti-inflammatory medications since they are relatively easy to prepare and very efficacious.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical / methods*
  • Drug Carriers / administration & dosage
  • Drug Carriers / pharmacokinetics
  • Drug Delivery Systems / methods*
  • Gels / administration & dosage*
  • Gels / pharmacokinetics
  • Hot Temperature*
  • Humans
  • Poloxamer / administration & dosage*
  • Poloxamer / pharmacokinetics


  • Drug Carriers
  • Gels
  • Poloxamer