1-O-alkylglycerols reduce the stimulating effects of bFGF on endothelial cell proliferation in vitro

Cancer Lett. 2007 Jun 28;251(2):317-22. doi: 10.1016/j.canlet.2006.11.028. Epub 2007 Jan 4.


1-O-alkylglycerols (alkyl-Gro) are natural etherlipids with multiple biological activities. We previously demonstrated that alkyl-Gro reduce endothelial permeability. Here we showed that alkyl-Gro reduced the basic Fibroblast Growth Factor (bFGF)-stimulated endothelial cell proliferation in a concentration-dependent manner. The effects of 0.5 and 5 ng/ml bFGF on growth were completely suppressed after 72 h-treatment by 50 microM alkyl-Gro. Since bFGF greatly increased (+56%+/-15) the production of 1-O-alkyl-2-acyl-sn-glycerophosphate in alkyl-Gro-treated endothelial cells, our data suggest that the observed effects of alkyl-Gro could be mediated through PLD activation. Inhibition of bFGF-stimulated endothelial proliferation could support anti-angiogenic activity of alkyl-Gro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors
  • Animals
  • Cattle
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Endothelial Cells / drug effects*
  • Endothelium, Vascular
  • Fibroblast Growth Factor 2 / pharmacology*
  • Glycerol / analogs & derivatives*
  • Glycerol / pharmacology
  • Glyceryl Ethers / pharmacology*
  • Tumor Cells, Cultured


  • Angiogenesis Inhibitors
  • Glyceryl Ethers
  • Fibroblast Growth Factor 2
  • Glycerol