Morphine and its metabolites: analytical methodologies for its determination

M Espinosa Bosch; A Ruiz Sánchez; F Sánchez Rojas; C Bosch Ojeda

doi:10.1016/j.jpba.2006.12.005

Morphine and its metabolites: analytical methodologies for its determination

J Pharm Biomed Anal. 2007 Feb 19;43(3):799-815. doi: 10.1016/j.jpba.2006.12.005. Epub 2006 Dec 15.

Authors

M Espinosa Bosch¹, A Ruiz Sánchez, F Sánchez Rojas, C Bosch Ojeda

Affiliation

¹ Department of Analytical Chemistry, Faculty of Sciences, University of Málaga, Campus Teatinos, 29071 Málaga, Spain.

PMID: 17207954
DOI: 10.1016/j.jpba.2006.12.005

Abstract

The present article reviews the methods of determination published for morphine and its metabolites covering the period from 1980 until at the first part of 2006. The overview includes the most relevant analytical determinations classified in the following two types: (1) non-chromatographic methods and (2) chromatographic methods.

Publication types

Review

MeSH terms

Analgesics, Opioid / analysis*
Analgesics, Opioid / pharmacokinetics
Animals
Biotransformation
Chromatography, Gas
Chromatography, High Pressure Liquid
Chromatography, Micellar Electrokinetic Capillary
Electrophoresis, Capillary
Humans
Morphine / analysis*
Morphine / pharmacokinetics

Substances

Analgesics, Opioid
Morphine