Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice

J Hepatol. 1991 Sep;13(2):220-6. doi: 10.1016/0168-8278(91)90818-v.


Insulin-like growth factor II (IGF-II) mRNA expression is developmentally regulated in liver tissue. We previously observed the reexpression of fetal IGF-II mRNAs in human primary liver cancer and in surrounding cirrhotic tissue. In order to determine the steps of liver cancer progression where the activation of IGF-II fetal mRNAs occurs, we analyzed IGF-II mRNA expression during hepatocarinogenesis in transgenic mice carrying an antithrombin III-SV40 early region hybrid gene. The comparative analysis of mRNAs encoding IGF-II and other differentiation-associated proteins, as well as histological analysis, indicate that the reexpression of fetal IGF-II mRNAs takes place in specific steps of liver cancer progression, both in early pretumorous lesions and in well-differentiated hepatocellular carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics
  • Aging / metabolism
  • Animals
  • Blotting, Northern
  • Insulin-Like Growth Factor II / genetics*
  • Insulin-Like Growth Factor II / metabolism
  • Liver Neoplasms, Experimental / genetics*
  • Liver Neoplasms, Experimental / metabolism
  • Mice
  • Mice, Transgenic
  • Ornithine Carbamoyltransferase / metabolism
  • RNA, Messenger / biosynthesis*
  • RNA, Messenger / isolation & purification
  • Simian virus 40 / genetics
  • alpha-Fetoproteins / metabolism


  • RNA, Messenger
  • alpha-Fetoproteins
  • Insulin-Like Growth Factor II
  • Ornithine Carbamoyltransferase