Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease

Mol Immunol. 2007 Apr;44(10):2497-506. doi: 10.1016/j.molimm.2006.11.025. Epub 2007 Jan 17.


The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hematologic Diseases / immunology*
  • Humans
  • Immune System Diseases / immunology*
  • Janus Kinases / metabolism*
  • Receptors, Cytokine / metabolism*
  • STAT Transcription Factors / metabolism*
  • Signal Transduction
  • Suppressor of Cytokine Signaling Proteins / metabolism*


  • Receptors, Cytokine
  • STAT Transcription Factors
  • Suppressor of Cytokine Signaling Proteins
  • Janus Kinases