Jak2: normal function and role in hematopoietic disorders

Curr Opin Genet Dev. 2007 Feb;17(1):8-14. doi: 10.1016/j.gde.2006.12.009. Epub 2007 Jan 8.

Abstract

Janus kinase 2 (Jak2) associates with cytokine receptors and is essential for signal transduction by mediating tyrosine phosphorylation. Kinase activity is regulated by a series of interactions beginning with the requirement to bind to specific domains in receptors, suppression of activation by the pseudokinase domain, and the requirement for phosphorylation within the activation loop. Recent studies have implicated de-regulation of Jak2 kinase activity by chromosomal translocations in hematopoietic tumors and mutations within the pseudokinase domain in a spectrum of myeloproliferative diseases.

Publication types

  • Review

MeSH terms

  • Gene Expression Regulation, Neoplastic*
  • Hematologic Neoplasms / genetics*
  • Humans
  • Janus Kinase 2 / metabolism*
  • Models, Molecular*
  • Mutation / genetics
  • Myeloproliferative Disorders / genetics*
  • Phosphorylation
  • Protein Structure, Tertiary
  • Receptors, Cytokine / metabolism
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Translocation, Genetic / genetics*
  • Tyrosine / metabolism

Substances

  • Receptors, Cytokine
  • Tyrosine
  • JAK2 protein, human
  • Janus Kinase 2