Cell cycle kinases in cancer

Curr Opin Genet Dev. 2007 Feb;17(1):60-5. doi: 10.1016/j.gde.2006.12.008.

Abstract

Cell division in mammalian cells is driven by protein kinases that regulate progression through the various phases of the cell cycle. Cyclin-dependent kinases (Cdks) regulate cell cycle commitment, DNA synthesis and the onset of mitosis. Kinases of the Aurora, Polo and Nek families participate in the centrosome cycle and modulate spindle function. Additional kinases such as Bub1, BubR1 and Mps1 regulate the spindle assembly checkpoint. It has been well established that misregulation of Cdks is one of the most frequent alterations in human cancer. Recent evidence indicates that mutations involving mitotic kinases are also linked to tumor development. These findings suggest novel strategies to use cell cycle kinases as targets for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aurora Kinases
  • Cell Cycle / genetics*
  • Cell Cycle / physiology
  • Cell Cycle Proteins / genetics
  • Cell Proliferation
  • Chromosome Aberrations*
  • Cyclin-Dependent Kinases / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Mutation / genetics
  • NIMA-Related Kinase 1
  • Neoplasms / genetics*
  • Neoplasms / physiopathology
  • Protein Kinases / genetics
  • Protein-Serine-Threonine Kinases / genetics
  • Proto-Oncogene Proteins / genetics

Substances

  • Cell Cycle Proteins
  • Proto-Oncogene Proteins
  • Protein Kinases
  • Aurora Kinases
  • BUB1 protein, human
  • Bub1 spindle checkpoint protein
  • NEK1 protein, human
  • NIMA-Related Kinase 1
  • Protein-Serine-Threonine Kinases
  • polo-like kinase 1
  • Cyclin-Dependent Kinases