A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium

Otolaryngol Head Neck Surg. 2007 Jan;136(1):72-7. doi: 10.1016/j.otohns.2006.07.010.


Objective: To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium.

Study design: A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status.

Results: The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed.

Conclusion: In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression.

Significance: This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antioxidants / analysis
  • Antioxidants / therapeutic use*
  • Chronic Disease
  • Coenzymes
  • Electron Transport Chain Complex Proteins / blood
  • Electron Transport Chain Complex Proteins / therapeutic use*
  • Female
  • Health Status Indicators
  • Humans
  • Male
  • Malondialdehyde / analysis
  • Middle Aged
  • Prospective Studies
  • Tinnitus / drug therapy*
  • Tinnitus / psychology
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / therapeutic use


  • Antioxidants
  • Coenzymes
  • Electron Transport Chain Complex Proteins
  • Ubiquinone
  • Malondialdehyde
  • coenzyme Q10