Double-blind, Placebo-Controlled Study of Fertilityblend: A Nutritional Supplement for Improving Fertility in Women

Clin Exp Obstet Gynecol. 2006;33(4):205-8.

Abstract

Purpose: To determine the impact of nutritional supplementation on female fertility.

Methods: A double blind, placebo-controlled study of the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry, green tea, L-arginine, vitamins (including folate) and minerals, on progesterone level, basal body temperature, menstrual cycle length, pregnancy rate and side-effects.

Results: Ninety-three (93) women, aged 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) group (N = 53) demonstrated a trend toward increased mean mid-luteal progesterone (P(ml)), but among women with basal pretreatment P(ml) < 9 ng/ml, the increase in progesterone was highly significant. The average number of days with luteal-phase basal temperatures over 98 degrees F increased significantly in the FB group. Both short and long cycles (< 27 days or > 32 days pretreatment) were normalized in the FB group. The placebo group (N = 40) did not show any significant changes in these parameters. After three months, 14 of the 53 women in the FB group were pregnant (26%) compared to four of the 40 women in the placebo group (10%; p = 0.01). Three additional women conceived after six months on FB (32%). No significant side-effects were noted.

Conclusion: Nutritional supplements could provide an alternative or adjunct to conventional fertility therapies.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arginine / administration & dosage
  • Body Temperature / drug effects
  • Camellia sinensis
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Infertility, Female / therapy*
  • Luteal Phase / drug effects
  • Minerals / administration & dosage
  • Phytotherapy
  • Progesterone / blood
  • Vitamins / administration & dosage
  • Vitex

Substances

  • Minerals
  • Vitamins
  • Progesterone
  • Arginine