Selective toxic effects of polyunsaturated fatty acids derived from Ulva fasciata on red tide phyotoplankter species

Biosci Biotechnol Biochem. 2007 Jan;71(1):265-8. doi: 10.1271/bbb.60475. Epub 2007 Jan 7.


Alpha-linolenic acid and linoleic acid isolated from Ulva fasciata showed toxic effects on red tide phytoplankters in a concentration-dependent manner. Among six species tested, raphidophycean flagellate Heterosigma akashiwo was the most susceptible to these fatty acids, and 50% lethal concentrations (LC50) of alpha-linolenic acid and linoleic acid were estimated to be 0.58 and 1.91 microg/ml respectively, whereas dinoflagellate Gymnodinium impudicum and Heterocapsa circularisquama were highly resistant and no significant toxic effects were observed up to 1,000 microg/ml. Both fatty acids were less toxic to fish (devil stinger), zooplankters (brine shrimp and rotifer), and mammalian cell lines (U937, HeLa, Vero, and CHO cells) than H. akashiwo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Survival / drug effects
  • Chlorocebus aethiops
  • Cricetinae
  • Dinoflagellida*
  • Fatty Acids, Unsaturated / chemistry*
  • Fatty Acids, Unsaturated / toxicity*
  • Humans
  • Phytoplankton / chemistry*
  • Ulva / chemistry*


  • Fatty Acids, Unsaturated