Cancer risks among BRCA1 and BRCA2 mutation carriers

Br J Cancer. 2007 Jan 15;96(1):11-5. doi: 10.1038/sj.bjc.6603535.


BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • BRCA2 Protein / genetics*
  • Breast Neoplasms / genetics*
  • Female
  • Humans
  • Male
  • Mutation
  • Ovarian Neoplasms / genetics*
  • Prostatic Neoplasms / genetics*
  • Risk Assessment
  • Risk Factors


  • BRCA1 Protein
  • BRCA2 Protein