[Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis]

Zhong Xi Yi Jie He Xue Bao. 2007 Jan;5(1):28-31. doi: 10.3736/jcim20070106.
[Article in Chinese]

Abstract

Objective: To study the effects of Salvia miltiorrhiza on serum levels of cytokines including interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) in patients with severe acute pancreatitis (SAP).

Methods: Thirty-six SAP patients were randomly divided into Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group with eighteen patients in each group. Fourteen age-matched healthy volunteers were assigned to control group. Serum levels of IL-6, IL-8, and TNF-alpha were tested within 24 hours of admission and 7 days after admission.

Results: Compared with those of the healthy volunteers, serum levels of the three cytokines of the SAP patients were significantly elevated (P<0.05). Serum levels of the three cytokines were significantly decreased in both Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group after 7-day treatment (P<0.05). The declining of the serum levels of the three cytokines in Salvia miltiorrhiza-treated group was more obvious than that in non-Salvia miltiorrhiza-treated group.

Conclusion: Salvia miltiorrhiza can treat SAP patients by reducing the serum levels of IL-6, IL-8, and TNF-alpha.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cytokines / blood*
  • Drugs, Chinese Herbal / therapeutic use
  • Female
  • Humans
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Male
  • Middle Aged
  • Pancreatitis, Acute Necrotizing / blood
  • Pancreatitis, Acute Necrotizing / drug therapy*
  • Phytotherapy*
  • Plant Preparations / therapeutic use*
  • Salvia miltiorrhiza / chemistry*
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Cytokines
  • Drugs, Chinese Herbal
  • Interleukin-6
  • Interleukin-8
  • Plant Preparations
  • Tumor Necrosis Factor-alpha