Patients with psychogenic nonepileptic seizures (PNES) and those with epilepsy may have very different medication use profiles. In this study, the authors set out to document and statistically compare medication use by these two populations. They found significant differences in the duration of antiepileptic medication use (shorter in those with psychogenic nonepileptic seizures, or PNES) and number of medications used (more in persons with PNES) and a tendency by patients with PNES to use narcotics and benzodiazepines. These results are discussed in the light of the pertinent literature.