This investigation was carried out on 233 workers from four wastewater treatment plants (WWTP). in order to detect the prevalence of hepatitis E. C and B viruses among those workers and the relationship of the prevalent viruses with schistosomal infection. The result showed that the highest single infection was with HEV and Schistosoma (50.6% and 50.4%, respectively) in the four (WWTP). For schistosomiasis infected workers, the coinfection with HEV and HCV were the highest single viral infection (63.9% and 40.2%, respectively). The combined infection with HEV+HCV in schistosomiasis workers was 35.3%, while for HCV-HBV was the lowest combined infection (9.0%). Therefore, it is very important to follow up these workers with the highest infection rate, as they can be potential risk group for the spread of viruses. Out of the four (WWTP), the workers at Helwan exhibited the highest infection rate.