TRP channels of the pancreatic beta cell

D A Jacobson; L H Philipson

doi:10.1007/978-3-540-34891-7_24

TRP channels of the pancreatic beta cell

Handb Exp Pharmacol. 2007:(179):409-24. doi: 10.1007/978-3-540-34891-7_24.

Authors

D A Jacobson¹, L H Philipson

Affiliation

¹ Department of Medicine-Endocrinology Section, University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA.

PMID: 17217070
DOI: 10.1007/978-3-540-34891-7_24

Abstract

Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.

Publication types

Review

MeSH terms

Animals
Humans
Insulin-Secreting Cells / drug effects
Insulin-Secreting Cells / metabolism
Insulin-Secreting Cells / physiology*
Ion Channels / drug effects
Ion Channels / metabolism
Ion Channels / physiology
Neurosecretory Systems / drug effects
Neurosecretory Systems / physiology
Transient Receptor Potential Channels / antagonists & inhibitors
Transient Receptor Potential Channels / metabolism
Transient Receptor Potential Channels / physiology*

Substances

Ion Channels
Transient Receptor Potential Channels