TRP channels of the pancreatic beta cell

Handb Exp Pharmacol. 2007;(179):409-24. doi: 10.1007/978-3-540-34891-7_24.

Abstract

Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Insulin-Secreting Cells / drug effects
  • Insulin-Secreting Cells / metabolism
  • Insulin-Secreting Cells / physiology*
  • Ion Channels / drug effects
  • Ion Channels / metabolism
  • Ion Channels / physiology
  • Neurosecretory Systems / drug effects
  • Neurosecretory Systems / physiology
  • Transient Receptor Potential Channels / antagonists & inhibitors
  • Transient Receptor Potential Channels / metabolism
  • Transient Receptor Potential Channels / physiology*

Substances

  • Ion Channels
  • Transient Receptor Potential Channels