[Systemic enzyme therapy in the treatment of children with lower orbital wall fractures]

Vestn Oftalmol. Nov-Dec 2006;122(6):20-3.
[Article in Russian]


Wobenzim, a drug for systemic enzyme therapy, was used in 26 children with lower orbital wall fractures as monotherapy in early periods (on days 1 to 7) after brain injury to improve healing conditions and to minimize the formation of scar tissues in the fractural area. A control group comprised 24 patients who received systemic dehydration and vessel-strengthening therapy. Systemic enzyme therapy with Wobenzim could reduce the attenuation time of inflammatory manifestations of injury, prevent complications, such as strangulation of the musculus rectus inferior in the fractural area and development of strangulated orbital soft tissue hernia, and substantially decrease the number of patients having indications for surgical plastic repair of the orbital wall, as compared with the control group.

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Adolescent
  • Child
  • Child, Preschool
  • Drug Combinations
  • Female
  • Fracture Healing
  • Humans
  • Hydrolases / administration & dosage
  • Hydrolases / therapeutic use*
  • Male
  • Orbit / surgery*
  • Orbital Fractures / diagnostic imaging
  • Orbital Fractures / drug therapy*
  • Orbital Fractures / surgery
  • Postoperative Complications / prevention & control
  • Rutin / administration & dosage
  • Rutin / therapeutic use*
  • Time Factors
  • Tomography, X-Ray Computed


  • Adjuvants, Immunologic
  • Drug Combinations
  • Rutin
  • Wobenzym
  • Hydrolases