Methimazole embryopathy: a contribution to defining the phenotype

Reprod Toxicol. 2007 Feb;23(2):253-5. doi: 10.1016/j.reprotox.2006.11.007. Epub 2006 Nov 28.

Abstract

It has been suggested that children prenatally exposed to methimazole may present some features in common but the phenotype remains to be defined. The reported facial features include upward slanted palpebral fissures, arched flared eyebrows and small nose with a broad bridge. Choanal atresia and other anomalies like esophageal atresia and aplasia cutis were also described with this embryopathy. Additionally, developmental delay was reported in some patients along with one of these major malformation. We present a patient with the mentioned facial features, developmental delay and radio-ulnar synostosis whose mother has been exposed to methimazole during pregnancy and any other ethiological cause could be recognize.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced*
  • Abnormalities, Multiple*
  • Antithyroid Agents / adverse effects*
  • Facies*
  • Humans
  • Infant
  • Male
  • Methimazole / adverse effects*
  • Phenotype
  • Radiography
  • Radius / abnormalities
  • Synostosis / chemically induced
  • Synostosis / diagnostic imaging
  • Ulna / abnormalities

Substances

  • Antithyroid Agents
  • Methimazole