Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Science. 2007 Jan 12;315(5809):207-12. doi: 10.1126/science.1132894.


We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport / genetics
  • DNA Transposable Elements
  • DNA, Protozoan / genetics
  • Gene Transfer, Horizontal
  • Genes, Protozoan
  • Genome, Protozoan*
  • Humans
  • Hydrogen / metabolism
  • Metabolic Networks and Pathways / genetics
  • Molecular Sequence Data
  • Multigene Family
  • Organelles / metabolism
  • Oxidative Stress / genetics
  • Peptide Hydrolases / genetics
  • Peptide Hydrolases / metabolism
  • Protozoan Proteins / genetics
  • Protozoan Proteins / physiology
  • RNA Processing, Post-Transcriptional
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA*
  • Sexually Transmitted Diseases / parasitology
  • Trichomonas Infections / parasitology
  • Trichomonas Infections / transmission
  • Trichomonas vaginalis / cytology
  • Trichomonas vaginalis / genetics*
  • Trichomonas vaginalis / metabolism
  • Trichomonas vaginalis / pathogenicity


  • DNA Transposable Elements
  • DNA, Protozoan
  • Protozoan Proteins
  • Hydrogen
  • Peptide Hydrolases

Associated data