Polycystic kidney disease is a risk factor for new-onset diabetes after transplantation

Transplantation. 2007 Jan 15;83(1):36-40. doi: 10.1097/01.tp.0000248759.37146.3d.


Background: Data from matched historical cohort studies suggest that autosomal-dominant polycystic kidney disease (ADPKD) may be a risk factor for new-onset diabetes after transplantation (NODAT).

Method: A retrospective study of 429 renal allografts transplanted from 1990 through 2004 in nondiabetic patients was performed. A multivariate analysis of risk factors for NODAT was performed with focus on ADPKD.

Results: A total of 6.5% of all patients developed NODAT and a further 11% developed impaired glucose tolerance. NODAT developed in 13.4% of patients with ADPKD compared with 5.2% of non-ADPKD patients (P=0.01). There were significant univariate associations between NODAT and recipient age (P=0.001) and weight (P<0.0001). There was no association between NODAT and recipient gender, human leukocyte antigen mismatch, acute rejection, or cumulative methylprednisolone dose. In a multivariate analysis, ADPKD was a strong risk factor for the development of NODAT (odds ratio [OR]=2.41, P=0.035) after correction for recipient age, weight, gender, ethnicity, and tacrolimus use. Age (OR=1.06), weight (OR=1.04), and nonwhite race (OR=5.04) were the other significant variables.

Conclusion: We conclude that ADPKD is a significant risk factor for the development of NODAT. This may influence the follow up and management choices of these patients in the future.

MeSH terms

  • Adult
  • Analysis of Variance
  • Blood Glucose / metabolism
  • Diabetes Mellitus / epidemiology*
  • Female
  • Graft Rejection / epidemiology
  • Graft Survival
  • Humans
  • Kidney Transplantation* / mortality
  • Kidney Transplantation* / physiology
  • Male
  • Middle Aged
  • Patient Selection
  • Polycystic Kidney Diseases / complications*
  • Postoperative Complications / physiopathology*
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Transplantation, Homologous


  • Blood Glucose