Time course of axonal regeneration in acute motor axonal neuropathy

Muscle Nerve. 2007 Jun;35(6):793-5. doi: 10.1002/mus.20729.

Abstract

Patients with acute motor axonal neuropathy (AMAN) generally recover well. We reviewed clinical and electrophysiologic recovery in 13 patients for up to 5 years. Twelve patients showed rapid recovery over 12 months, whereas in the remaining one the recovery was slow and incomplete at 5 years. In AMAN, axonal degeneration appears to develop predominantly in the motor nerve terminals, and only occasionally more proximally in the nerve roots. Nerve terminal degeneration-regeneration presumably provides a mechanism for good recovery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Axons* / pathology
  • Disease Progression
  • Electromyography
  • Female
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / pathology
  • Guillain-Barre Syndrome / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Motor Neurons* / pathology
  • Nerve Regeneration*
  • Neural Conduction
  • Peripheral Nerves / pathology
  • Peripheral Nerves / physiopathology*
  • Presynaptic Terminals / pathology
  • Recovery of Function*
  • Time Factors
  • Wallerian Degeneration / etiology
  • Wallerian Degeneration / pathology
  • Wallerian Degeneration / physiopathology