Abstract
Patients with acute motor axonal neuropathy (AMAN) generally recover well. We reviewed clinical and electrophysiologic recovery in 13 patients for up to 5 years. Twelve patients showed rapid recovery over 12 months, whereas in the remaining one the recovery was slow and incomplete at 5 years. In AMAN, axonal degeneration appears to develop predominantly in the motor nerve terminals, and only occasionally more proximally in the nerve roots. Nerve terminal degeneration-regeneration presumably provides a mechanism for good recovery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Axons* / pathology
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Disease Progression
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Electromyography
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Female
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Guillain-Barre Syndrome / diagnosis
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Guillain-Barre Syndrome / pathology
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Guillain-Barre Syndrome / physiopathology*
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Humans
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Male
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Middle Aged
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Motor Neurons* / pathology
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Nerve Regeneration*
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Neural Conduction
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Peripheral Nerves / pathology
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Peripheral Nerves / physiopathology*
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Presynaptic Terminals / pathology
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Recovery of Function*
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Time Factors
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Wallerian Degeneration / etiology
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Wallerian Degeneration / pathology
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Wallerian Degeneration / physiopathology